Clinical PK studies
- Phase I dose-escalation study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of an inhaled recombinant human ACE2
- Colistin Reduces LPS-Triggered Inflammation in a Human Sepsis Model In Vivo: A Randomized Controlled Trial
- A FIM Study to Assess Safety and Exposure of Inhaled Single Doses of AP301—A Specific ENaC Channel Activator for the Treatment of Acute Lung Injury
- Safety and immunogenicity of a novel multivalent OspA vaccine against Lyme borreliosis in healthy adults: a double-blind, randomised, dose-escalation phase 1/2 trialWressnigg, Lancet Infect Dis, 2013 (Zeitlinger, Muller)
- Combined Pharmacokinetics of Piperacillin and Tazobactam in Critically Ill Patients: An Integral Population Pharmacokinetic Model in Plasma and Urine
Clinical target site PK studies
- Target-site cefiderocol pharmacokinetics in soft tissues of healthy volunteers
- Pharmacokinetics of doripenem in plasma and epithelial lining fluid (ELF): comparison of two dosage regimens
- Target Site Pharmacokinetics of Linezolid After Single and Multiple Doses in Diabetic Patients With Soft Tissue InfectionEslam, J Clin Pharmacol, 2014 (Zeitlinger)
- Simultaneous assessment of the pharmacokinetics of a pleuromutilin in epithelial lining fluid and soft tissue
PKPD modeling
- Pharmacokinetic/pharmacodynamic model-based optimization of temocillin dosing strategies for the treatment of systemic infections
- Physiologically Based Modelling Framework for Prediction of Pulmonary Pharmacokinetics of Antimicrobial Target Site Concentrations
- Predictions of Bedaquiline Central Nervous System Exposure in Patients with Tuberculosis Meningitis Using Physiologically based Pharmacokinetic Modeling
- Structure-Based Prediction of Anti-infective Drug Concentrations in the Human Lung Epithelial Lining Fluid
- Model-based dose optimization framework for bedaquiline, pretomanid and linezolid for the treatment of drug-resistant tuberculosis
- Prediction of Bedaquiline and Pretomanid Site-of-Action Exposures in Tuberculosis Patients Using Physiologically based Pharmacokinetic Modeling
- Semisynthetic guanidino lipoglycopeptides with potent in vitro and in vivo antimicrobial activity
- Pharmacodynamic evaluation of antibiotic combinations in murine thigh infection model
- Combined Pharmacokinetics of Piperacillin and Tazobactam in Critically Ill Patients: An Integral Population Pharmacokinetic Model in Plasma and Urine
Anti-infective PK bioanalytical methods
- Development and validation of a bioanalytical assay for the measurement of total and unbound teicoplanin in human serum
- Pharmacokinetic investigations of isavuconazole in paediatric cancer patients show reduced exposure of isavuconazole after opening capsules for administration via a nasogastric tube
- Simultaneous assessment of the pharmacokinetics of a pleuromutilin in epithelial lining fluid and soft tissue
- Target-site cefiderocol pharmacokinetics in soft tissues of healthy volunteers
- Development and validation of a liquid chromatography-mass spectrometry method for the measurement of seven antibiotics
Translational in vitro and in vivo models
- Pharmacokinetic/pharmacodynamic model-based optimization of temocillin dosing strategies for the treatment of systemic infections
- Model-based dose optimization framework for bedaquiline, pretomanid and linezolid for the treatment of drug-resistant tuberculosis
- Pharmacodynamic evaluation of antibiotic combinations in murine thigh infection model
- Semisynthetic guanidino lipoglycopeptides with potent in vitro and in vivo antimicrobial activity
- Pharmacodynamics of Temocillin in Neutropenic Murine Thigh Infection Model
- Pharmacodynamics of Flucloxacillin in a Neutropenic Murine Thigh Infection Model: A Piece of the Puzzle towards Evidence-Based Dosing
- Pharmacokinetic/Pharmacodynamic evaluation in neutropenic murine infection models
- Pharmacodynamic evaluation of antibiotic combinations in neutropenic murine thigh infection model
- Pharmacokinetic/pharmacodynamic evaluation in murine thigh infection model
- Pharmacodynamic evaluation in murine thigh and lung infection models